CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Urokinase-type plasminogen activator

Enzyme Information

3.4.21.73
U-plasminogen activator.
based on mapping to UniProt P00749
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
-!- Formed from the inactive precursor by action of plasmin or plasma kallikrein. -!- Differs in structure from EC 3.4.21.68, and does not bind to fibrin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.31 and EC 3.4.99.26.

UniProtKB Entries (1)

P00749
UROK_HUMAN
Homo sapiens
Urokinase-type plasminogen activator

PDB Structure

PDB 1GJC
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets.
Katz, B.A., Sprengeler, P.A., Luong, C., Verner, E., Elrod, K., Kirtley, M., Janc, J., Spencer, J.R., Breitenbucher, J.G., Hui, H., McGee, D., Allen, D., Martelli, A., Mackman, R.L.
Chem.Biol.