CATH Classification

Domain Context

CATH Clusters

Superfamily Methylglyoxal synthase-like domain
Functional Family

Enzyme Information

3.5.4.10
IMP cyclohydrolase.
based on mapping to UniProt P31335
IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
2.1.2.3
Phosphoribosylaminoimidazolecarboxamide formyltransferase.
based on mapping to UniProt P31335
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.

UniProtKB Entries (1)

P31335
PUR9_CHICK
Gallus gallus
Bifunctional purine biosynthesis protein PURH

PDB Structure

PDB 1G8M
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis.
Greasley, S.E., Horton, P., Ramcharan, J., Beardsley, G.P., Benkovic, S.J., Wilson, I.A.
Nat.Struct.Biol.