CATH Classification

Domain Context

CATH Clusters

Superfamily DNA Methylase, subunit A, domain 2
Functional Family DNA (5-cytosine) methyltransferase homolog

Enzyme Information
tRNA (cytosine(38)-C(5))-methyltransferase.
based on mapping to UniProt O14717
S-adenosyl-L-methionine + cytosine(38) in tRNA = S-adenosyl-L- homocysteine + 5-methylcytosine(38) in tRNA.
-!- The eukaryotic enzyme catalyzes methylation of cytosine(38) in the anti-codon loop of tRNA(Asp)(GTC), tRNA(Val)(AAC) and tRNA(Gly)(GCC). -!- Methylation by Dnmt2 protects tRNAs against stress-induced cleavage by ribonuclease. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
TRNA (cytosine(38)-C(5))-methyltransferase

PDB Structure

PDB 1G55
External Links
Organism Escherichia
Primary Citation
Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA.
Dong, A., Yoder, J.A., Zhang, X., Zhou, L., Bestor, T.H., Cheng, X.
Nucleic Acids Res.