CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Complement factor D

Enzyme Information

3.4.21.79
Granzyme B.
based on mapping to UniProt P10144
Preferential cleavage: -Asp-|-Xaa- >> -Asn-|-Xaa- > -Met-|-Xaa-, -Ser-|-Xaa-.
-!- From cytotoxic T lymphocyte granules. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P10144
GRAB_HUMAN
Homo sapiens
Granzyme B

PDB Structure

PDB 1FQ3
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue.
Estebanez-Perpina, E., Fuentes-Prior, P., Belorgey, D., Braun, M., Kiefersauer, R., Maskos, K., Huber, R., Rubin, H., Bode, W.
Biol.Chem.