CATH Classification

Domain Context

CATH Clusters

Superfamily D-Amino Acid Oxidase, subunit A, domain 2
Functional Family

Enzyme Information

1.14.13.7
Phenol 2-monooxygenase (NADPH).
based on mapping to UniProt P15245
Phenol + NADPH + O(2) = catechol + NADP(+) + H(2)O.
-!- The enzyme from the fungus Trichosporon cutaneum has a broad substrate specificity, and has been reported to catalyze the hydroxylation of a variety of substituted phenols, such as fluoro-, chloro-, amino- and methyl-phenols and also dihydroxybenzenes. -!- Cf. EC 1.14.14.20.

UniProtKB Entries (1)

P15245
PHHY_TRICU
Cutaneotrichosporon cutaneum
Phenol hydroxylase

PDB Structure

PDB 1FOH
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The crystal structure of phenol hydroxylase in complex with FAD and phenol provides evidence for a concerted conformational change in the enzyme and its cofactor during catalysis.
Enroth, C., Neujahr, H., Schneider, G., Lindqvist, Y.
Structure