CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family Coagulation factor XIII A chain

Enzyme Information

2.3.2.13
Protein-glutamine gamma-glutamyltransferase.
based on mapping to UniProt P00488
A protein-L-glutamine + a protein-L-lysine = a protein with an N(6)- (gamma-glutamyl)-L-lysine cross-link + NH(3).
-!- The gamma-carboxymide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N(6)-(5-glutamyl)lysine cross-links.

UniProtKB Entries (1)

P00488
F13A_HUMAN
Homo sapiens
Coagulation factor XIII A chain

PDB Structure

PDB 1FIE
External Links
Method X-RAY DIFFRACTION
Organism Saccharomyces
Primary Citation
Structural evidence that the activation peptide is not released upon thrombin cleavage of factor XIII.
Yee, V.C., Pedersen, L.C., Bishop, P.D., Stenkamp, R.E., Teller, D.C.
Thromb.Res.