CATH Classification

Domain Context

CATH Clusters

Superfamily Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family Thymidylate synthase

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt P0A884
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

P0A884
TYSY_ECOLI
Escherichia coli K-12
Thymidylate synthase

PDB Structure

PDB 1FFL
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of thymidylate synthase mutant R166Q: Structural basis for the nearly complete loss of catalytic activity.
Sotelo-Mundo, R.R., Changchien, L., Maley, F., Montfort, W.R.
J.Biochem.Mol.Toxicol.