CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphoglycerate mutase-like
Functional Family 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2

Enzyme Information

2.7.1.105
6-phosphofructo-2-kinase.
based on mapping to UniProt P07953
ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.
-!- Not identical with EC 2.7.1.11. -!- The enzyme copurifies with EC 3.1.3.46.
3.1.3.46
Fructose-2,6-bisphosphate 2-phosphatase.
based on mapping to UniProt P07953
Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.
-!- The enzyme copurifies with EC 2.7.1.105 (cf. EC 3.1.3.54).

UniProtKB Entries (1)

P07953
F261_RAT
Rattus norvegicus
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

PDB Structure

PDB 1FBT
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the rat liver fructose-2,6-bisphosphatase based on selenomethionine multiwavelength anomalous dispersion phases.
Lee, Y.H., Ogata, C., Pflugrath, J.W., Levitt, D.G., Sarma, R., Banaszak, L.J., Pilkis, S.J.
Biochemistry