CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Diacylglycerol acyltransferase/mycolyltransferase Ag85C

Enzyme Information

2.3.1.20
Diacylglycerol O-acyltransferase.
based on mapping to UniProt P9WQP1
Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
-!- Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.
2.3.1.122
Trehalose O-mycolyltransferase.
based on mapping to UniProt P9WQP1
2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose + alpha,alpha'-trehalose 6,6'-bismycolate.
-!- Catalyzes the exchange of mycolic acid between trehalose, trehalose mycolate and trehalose bismycolate. -!- Trehalose 6-palmitate can also act as donor.

UniProtKB Entries (1)

P9WQP1
A85B_MYCTU
Mycobacterium tuberculosis H37Rv
Diacylglycerol acyltransferase/mycolyltransferase Ag85B

PDB Structure

PDB 1F0N
External Links
Method X-RAY DIFFRACTION
Organism Mycobacterium
Primary Citation
An interfacial mechanism and a class of inhibitors inferred from two crystal structures of the Mycobacterium tuberculosis 30 kDa major secretory protein (Antigen 85B), a mycolyl transferase.
Anderson, D.H., Harth, G., Horwitz, M.A., Eisenberg, D.
J.Mol.Biol.