CATH Classification

Domain Context

CATH Clusters

Superfamily PtsI, HPr-binding domain
Functional Family Phosphoenolpyruvate-protein phosphotransferase

Enzyme Information

2.7.3.9
Phosphoenolpyruvate--protein phosphotransferase.
based on mapping to UniProt P08839
Phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)- phospho-L-histidine.
-!- Acts only on histidine residues in specific phosphocarrier proteins of low molecular mass (9.5 kDa) involved in bacterial sugar transport. -!- A similar reaction where the protein is the enzyme EC 2.7.9.2 is part of the mechanism of that enzyme.

UniProtKB Entries (1)

P08839
PT1_ECOLI
Escherichia coli K-12
Phosphoenolpyruvate-protein phosphotransferase

PDB Structure

PDB 1EZA
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Solution structure of the 30 kDa N-terminal domain of enzyme I of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system by multidimensional NMR.
Garrett, D.S., Seok, Y.J., Liao, D.I., Peterkofsky, A., Gronenborn, A.M., Clore, G.M.
Biochemistry