CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Enzyme Information

1.1.1.8
Glycerol-3-phosphate dehydrogenase (NAD(+)).
based on mapping to UniProt P90551
sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH.
-!- Also acts on propane-1,2-diol phosphate and glycerone sulfate (but with a much lower affinity).

UniProtKB Entries (1)

P90551
GPDA_LEIME
Leishmania mexicana
Glycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal

PDB Structure

PDB 1EVZ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana.
Suresh, S., Turley, S., Opperdoes, F.R., Michels, P.A., Hol, W.G.
Structure Fold.Des.