CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family Fibroblast growth factor receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P21802
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P09038
FGF2_HUMAN
Homo sapiens
Fibroblast growth factor 2

PDB Structure

PDB 1EV2
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Plotnikov, A.N., Hubbard, S.R., Schlessinger, J., Mohammadi, M.
Cell(Cambridge,Mass.)