CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00735
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (1)

P00735
THRB_BOVIN
Bos taurus
Prothrombin

PDB Structure

PDB 1ETS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics.
Brandstetter, H., Turk, D., Hoeffken, H.W., Grosse, D., Sturzebecher, J., Martin, P.D., Edwards, B.F., Bode, W.
J.Mol.Biol.