CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P62593
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P62593
BLAT_ECOLX
Escherichia coli
Beta-lactamase TEM

PDB Structure

PDB 1ERO
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,).
Ness, S., Martin, R., Kindler, A.M., Paetzel, M., Gold, M., Jensen, S.E., Jones, J.B., Strynadka, N.C.
Biochemistry