CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family 3-hydroxyacyl-CoA dehydrogenase type-2

Enzyme Information

1.1.1.178
3-hydroxy-2-methylbutyryl-CoA dehydrogenase.
based on mapping to UniProt O70351
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methylacetoacetyl-CoA + NADH.
-!- Also acts, more slowly, on (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA.
1.1.1.51
3(or 17)-beta-hydroxysteroid dehydrogenase.
based on mapping to UniProt O70351
Testosterone + NAD(P)(+) = androst-4-ene-3,17-dione + NAD(P)H.
-!- Also acts on other 3-beta- or 17-beta-hydroxysteroids (cf. EC 1.1.1.209).
1.1.1.35
3-hydroxyacyl-CoA dehydrogenase.
based on mapping to UniProt O70351
(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
-!- Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate. -!- Some enzymes act, more slowly, with NADP(+). -!- Broad specificity to acyl chain-length (cf. EC 1.1.1.211).

UniProtKB Entries (1)

O70351
HCD2_RAT
Rattus norvegicus
3-hydroxyacyl-CoA dehydrogenase type-2

PDB Structure

PDB 1E3W
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Recognition of Structurally Diverse Substrates by Type II 3-Hydroxyacyl-Coa Dehydrogenase (Hadh II) Amyloid-Beta Binding Alcohol Dehydrogenase (Abad)
Powell, A.J., Read, J.A., Banfield, M.J., Gunn-Moore, F., Yan, S.D., Lustbader, J., Stern, A.R., Stern, D.M., Brady, R.L.
J.Mol.Biol.