CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family S-(hydroxymethyl)glutathione dehydrogenase

Enzyme Information

1.1.1.1
Alcohol dehydrogenase.
based on mapping to UniProt Q9QYY9
(1) A primary alcohol + NAD(+) = an aldehyde + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
-!- Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. -!- The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.

UniProtKB Entries (1)

Q9QYY9
ADH4_MOUSE
Mus musculus
Alcohol dehydrogenase 4

PDB Structure

PDB 1E3I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Mouse Class II Alcohol Dehydrogenase Reveal Determinants of Substrate Specificity and Catalytic Efficiency
Svensson, S., Hoeoeg, J.O., Schneider, G., Sandalova, T.
J.Mol.Biol.