CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphoenolpyruvate-binding domains
Functional Family Pyruvate kinase

Enzyme Information

2.7.1.40
Pyruvate kinase.
based on mapping to UniProt P0AD61
ATP + pyruvate = ADP + phosphoenolpyruvate.
-!- UTP, GTP, CTP, ITP and dATP can also act as donors. -!- Also phosphorylates hydroxylamine and fluoride in the presence of CO(2).

UniProtKB Entries (1)

P0AD61
KPYK1_ECOLI
Escherichia coli K-12
Pyruvate kinase I

PDB Structure

PDB 1E0T
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Allosteric Regulation of Pyruvate Kinase.
Valentini, G., Chiarelli, L., Fortin, R., Speranza, M.L., Galizzi, A., Mattevi, A.
J.Biol.Chem.