CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P04190
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P04190
BLA2_BACCE
Bacillus cereus
Metallo-beta-lactamase type 2

PDB Structure

PDB 1DXK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural effects of the active site mutation cysteine to serine in Bacillus cereus zinc-beta-lactamase.
Chantalat, L., Duee, E., Galleni, M., Frere, J.M., Dideberg, O.
Protein Sci.