CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase C10 family
Functional Family

Enzyme Information

3.4.22.10
Streptopain.
based on mapping to UniProt P0C0J0
Preferential cleavage with hydrophobic residues at P2, P1 and P1'.
-!- From the bacterium, group A Streptococcus. -!- Formed from the proenzyme by limited proteolysis. -!- Belongs to peptidase family C10. -!- Formerly EC 3.4.4.18.

UniProtKB Entries (1)

P0C0J0
SPEB_STRPY
Streptococcus pyogenes
Streptopain

PDB Structure

PDB 1DKI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the zymogen form of the group A Streptococcus virulence factor SpeB: an integrin-binding cysteine protease.
Kagawa, T.F., Cooney, J.C., Baker, H.M., McSweeney, S., Liu, M., Gubba, S., Musser, J.M., Baker, E.N.
Proc.Natl.Acad.Sci.USA