CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (1)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin

PDB Structure

PDB 1DIT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic.
Krishnan, R., Tulinsky, A., Vlasuk, G.P., Pearson, D., Vallar, P., Bergum, P., Brunck, T.K., Ripka, W.C.
Protein Sci.