CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family

Enzyme Information

1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P00381
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P00381
DYR_LACCA
Lactobacillus casei
Dihydrofolate reductase

PDB Structure

PDB 1DIS
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Solution structure of a brodimoprim analogue in its complex with Lactobacillus casei dihydrofolate reductase.
Morgan, W.D., Birdsall, B., Polshakov, V.I., Sali, D., Kompis, I., Feeney, J.
Biochemistry