CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Cathepsin B

Enzyme Information

3.4.22.1
Cathepsin B.
based on mapping to UniProt P00787
Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.
-!- An intracellular (lysosomal) enzyme. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P00787
CATB_RAT
Rattus norvegicus
Cathepsin B

PDB Structure

PDB 1CPJ
External Links
Method X-RAY DIFFRACTION
Organism Saccharomyces
Primary Citation
Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design.
Jia, Z., Hasnain, S., Hirama, T., Lee, X., Mort, J.S., To, R., Huber, C.P.
J.Biol.Chem.