CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family 72 kDa type IV collagenase

Enzyme Information

3.4.24.24
Gelatinase A.
based on mapping to UniProt P08253
Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln.
-!- Belongs to peptidase family M10B.

UniProtKB Entries (1)

P08253
MMP2_HUMAN
Homo sapiens
72 kDa type IV collagenase

PDB Structure

PDB 1CK7
External Links
Method X-RAY DIFFRACTION
Organism Trichoplusia
Primary Citation
Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed.
Morgunova, E., Tuuttila, A., Bergmann, U., Isupov, M., Lindqvist, Y., Schneider, G., Tryggvason, K.
Science