CATH Classification

Domain Context

CATH Clusters

Superfamily C2 domain
Functional Family Phospholipase A2

Enzyme Information

3.1.1.4
Phospholipase A(2).
based on mapping to UniProt P47712
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
-!- Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position.
3.1.1.5
Lysophospholipase.
based on mapping to UniProt P47712
2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.

UniProtKB Entries (1)

P47712
PA24A_HUMAN
Homo sapiens
Cytosolic phospholipase A2

PDB Structure

PDB 1CJY
External Links
Method X-RAY DIFFRACTION
Organism Cricetulus
Primary Citation
Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism.
Dessen, A., Tang, J., Schmidt, H., Stahl, M., Clark, J.D., Seehra, J., Somers, W.S.
Cell(Cambridge,Mass.)