CATH Classification

Domain Context

CATH Clusters

Superfamily Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain
Functional Family L-aspartate oxidase

Enzyme Information

1.4.3.16
L-aspartate oxidase.
based on mapping to UniProt P10902
L-aspartate + O(2) = iminosuccinate + H(2)O(2).
-!- L-aspartate oxidase catalyzes the first step in the de novo biosynthesis of NAD(+) in some bacteria. -!- O(2) can be replaced by fumarate as electron acceptor, yielding succinate. -!- The ability of the enzyme to use both O(2) and fumarate in cofactor reoxidation enables it to function under both aerobic and anaerobic conditions. -!- Iminosuccinate can either be hydrolyzed to form oxaloacetate and NH(3) or can be used by EC 2.5.1.72 in the production of quinolinate.

UniProtKB Entries (1)

P10902
NADB_ECOLI
Escherichia coli K-12
L-aspartate oxidase

PDB Structure

PDB 1CHU
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of L-aspartate oxidase: implications for the succinate dehydrogenase/fumarate reductase oxidoreductase family.
Mattevi, A., Tedeschi, G., Bacchella, L., Coda, A., Negri, A., Ronchi, S.
Structure Fold.Des.