CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin
P28504
HIR2_HIRME
Hirudo medicinalis
Hirudin-2

PDB Structure

PDB 1C1W
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design of potent selective zinc-mediated serine protease inhibitors.
Katz, B.A., Clark, J.M., Finer-Moore, J.S., Jenkins, T.E., Johnson, C.R., Ross, M.J., Luong, C., Moore, W.R., Stroud, R.M.
Nature