CATH Classification

Domain Context

CATH Clusters

Superfamily Divalent-metal-dependent TIM barrel enzymes
Functional Family

Enzyme Information

5.3.1.5
Xylose isomerase.
based on mapping to UniProt P26997
D-xylopyranose = D-xylulose.
-!- The enzyme catalyzes the interconversion of aldose and ketose sugars with broad substrate specificity. -!- The enzyme binds the closed form of its sugar substrate (in the case of glucose, only the alpha anomer) and catalyzes ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites. -!- Isomerization proceeds via a hydride-shift mechanism.

UniProtKB Entries (1)

P26997
XYLA_THET8
Thermus thermophilus HB8
Xylose isomerase

PDB Structure

PDB 1BXB
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of thermostable xylose isomerases from Thermus caldophilus and Thermus thermophilus: possible structural determinants of thermostability.
Chang, C., Park, B.C., Lee, D.S., Suh, S.W.
J.Mol.Biol.