CATH Classification

Domain Context

CATH Clusters

Superfamily Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q06187
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q06187
BTK_HUMAN
Homo sapiens
Tyrosine-protein kinase BTK

PDB Structure

PDB 1BWN
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate.
Baraldi, E., Carugo, K.D., Hyvonen, M., Surdo, P.L., Riley, A.M., Potter, B.V., O'Brien, R., Ladbury, J.E., Saraste, M.
Structure Fold.Des.