CATH Classification

Domain Context

CATH Clusters

Superfamily Butyryl-CoA Dehydrogenase, subunit A, domain 3
Functional Family Acyl-CoA dehydrogenase FadE25

Enzyme Information

1.3.8.1
Short-chain acyl-CoA dehydrogenase.
based on mapping to UniProt Q06319
A short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
-!- One of several enzymes that catalyze the first step in fatty acids beta-oxidation. -!- The enzyme catalyzes the oxidation of saturated short-chain acyl-CoA thioesters to give a trans 2,3-unsaturated product by removal of the two pro-R hydrogen atoms. -!- The enzyme from beef liver accepts substrates with acyl chain lengths of 3 to 8 carbon atoms. -!- The highest activity was reported with either butanoyl-CoA or pentanoyl-CoA. -!- The enzyme from rat has only 10% activity with hexanoyl-CoA (compared to butanoyl-CoA) and no activity with octanoyl-CoA. -!- Cf. EC 1.3.8.7, EC 1.3.8.8 and EC 1.3.8.9. -!- Formerly EC 1.3.2.1 and EC 1.3.99.2.

UniProtKB Entries (1)

Q06319
ACDS_MEGEL
Megasphaera elsdenii
Acyl-CoA dehydrogenase, short-chain specific

PDB Structure

PDB 1BUC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Three-dimensional structure of butyryl-CoA dehydrogenase from Megasphaera elsdenii.
Djordjevic, S., Pace, C.P., Stankovich, M.T., Kim, J.J.
Biochemistry