CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Collagenase 3

Enzyme Information

3.4.24.17
Stromelysin 1.
based on mapping to UniProt P08254
Preferential cleavage where P1', P2' and P3' are hydrophobic residues.
-!- Extracellular endopeptidase of vertebrate tissues. -!- Degradation of proteoglycans, fibronectin, collagen type III, IV, V and IX and activates procollagenase. -!- Belongs to peptidase family M10B.

UniProtKB Entries (1)

P08254
MMP3_HUMAN
Homo sapiens
Stromelysin-1

PDB Structure

PDB 1BIW
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Design and synthesis of conformationally-constrained MMP inhibitors.
Natchus, M.G., Cheng, M., Wahl, C.T., Pikul, S., Almstead, N.G., Bradley, R.S., Taiwo, Y.O., Mieling, G.E., Dunaway, C.M., Snider, C.E., McIver, J.M., Barnett, B.L., McPhail, S.J., Anastasio, M.B., De, B.
Bioorg.Med.Chem.Lett.