CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (1)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin

PDB Structure

PDB 1B7X
External Links
Method X-RAY DIFFRACTION
Organism Saccharomyces
Primary Citation
Unexpected crucial role of residue 225 in serine proteases.
Guinto, E.R., Caccia, S., Rose, T., Futterer, K., Waksman, G., Di Cera, E.
Proc.Natl.Acad.Sci.USA