CATH Classification

Domain Context

CATH Clusters

Superfamily 6-pyruvoyl tetrahydropterin synthase/QueD
Functional Family 6-pyruvoyl tetrahydrobiopterin synthase

Enzyme Information

4.2.3.12
6-pyruvoyltetrahydropterin synthase.
based on mapping to UniProt P27213
7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8- tetrahydropterin + triphosphate.
-!- Catalyzes triphosphate elimination and an intramolecular redox reaction. -!- The product is 6-pyruvoyltetrahydrobiopterin. -!- Involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 and EC 3.5.4.16. -!- Formerly EC 4.6.1.10.

UniProtKB Entries (1)

P27213
PTPS_RAT
Rattus norvegicus
6-pyruvoyl tetrahydrobiopterin synthase

PDB Structure

PDB 1B66
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase.
Ploom, T., Thony, B., Yim, J., Lee, S., Nar, H., Leimbacher, W., Richardson, J., Huber, R., Auerbach, G.
J.Mol.Biol.