CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin
P01050
HIRV1_HIRME
Hirudo medicinalis
Hirudin variant-1

PDB Structure

PDB 1AY6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Novel thrombin inhibitors that are based on a macrocyclic tripeptide motif
Greco, M.N., Powell, E.T., Hecker, L.R., Andrade-Gordon, P., Kauffman, J.A., Lewis, J.M., Ganesh, V., Tulinsky, A., Maryanoff, B.E.
Bioorg.Med.Chem.Lett.