CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Disintegrin and metalloproteinase domain-containing protein 22

Enzyme Information

3.4.24.42
Atrolysin C.
based on mapping to UniProt P15167
Cleavage of 5-His-|-Leu-6, 10-His-|-Leu-11, 14-Ala-|-Leu-15, 16-Tyr-|-Leu-17 and 23-Gly-|-Phe-24 of insulin B chain. With small molecule substrates prefers hydrophobic residue at P2' and small residue such as Ala, Gly at P1.
-!- Hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox). -!- Exist as two forms, c and d. -!- Digests type IV collagen. -!- Phosphoramidon inhibits in the 0.1 mM range. -!- Hemorrhagic toxin-2 of C.ruber ruber has the same molecular weight and specificity. -!- Belongs to peptidase family M12B.

UniProtKB Entries (1)

P15167
VM1AD_CROAT
Crotalus atrox
Snake venom metalloproteinase atrolysin-D

PDB Structure

PDB 1ATL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural interaction of natural and synthetic inhibitors with the venom metalloproteinase, atrolysin C (form d).
Zhang, D., Botos, I., Gomis-Ruth, F.X., Doll, R., Blood, C., Njoroge, F.G., Fox, J.W., Bode, W., Meyer, E.F.
Proc.Natl.Acad.Sci.USA