CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Endothiapepsin

Enzyme Information

3.4.23.20
Penicillopepsin.
based on mapping to UniProt P00798
Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving 20-Gly-|-Glu-21 in the B chain of insulin. Clots milk, and activates trypsinogen.
-!- From the imperfect fungus Penicillium janthinellum. -!- Closely related enzymes have been isolated from P.roqueforti and P.duponti. -!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.17, EC 3.4.23.6 and EC 3.4.23.7.

UniProtKB Entries (1)

P00798
PEPA1_PENJA
Penicillium janthinellum
Penicillopepsin-1

PDB Structure

PDB 1APV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystallographic analysis of transition state mimics bound to penicillopepsin: difluorostatine- and difluorostatone-containing peptides.
James, M.N., Sielecki, A.R., Hayakawa, K., Gelb, M.H.
Biochemistry