CATH Classification

CATH Clusters

Superfamily NADPH-cytochrome p450 Reductase; Chain A, domain 3
Functional Family Nitric oxide synthase 1

Enzyme Information

1.6.2.4
NADPH--hemoprotein reductase.
based on mapping to UniProt P00388
NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.
-!- The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction. -!- The enzyme catalyzes the reduction of the heme-thiolate-dependent monooxygenases, such as EC 1.14.14.1, and reduction of EC 1.14.99.3. -!- It is part of the microsomal hydroxylating system. -!- It also reduces cytochrome b5 and cytochrome c.

UniProtKB Entries (1)

P00388
NCPR_RAT
Rattus norvegicus
NADPH--cytochrome P450 reductase

PDB Structure

PDB 1AMO
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes.
Wang, M., Roberts, D.L., Paschke, R., Shea, T.M., Masters, B.S., Kim, J.J.
Proc.Natl.Acad.Sci.USA