CATH Classification

Domain Context

CATH Clusters

Superfamily Aconitase, Domain 2
Functional Family Aconitate hydratase, mitochondrial

Enzyme Information

4.2.1.3
Aconitate hydratase.
based on mapping to UniProt P20004
Citrate = isocitrate.
-!- Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate. -!- The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate. -!- Cis-aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3- tricarboxylate. -!- Formerly EC 4.2.1.4.

UniProtKB Entries (1)

P20004
ACON_BOVIN
Bos taurus
Aconitate hydratase, mitochondrial

PDB Structure

PDB 1AMI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Steric and conformational features of the aconitase mechanism.
Lauble, H., Stout, C.D.
Proteins