CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.1360.40
Functional Family DNA gyrase subunit A

Enzyme Information

5.6.2.3
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt P0AES4
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

P0AES4
GYRA_ECOLI
Escherichia coli K-12
DNA gyrase subunit A

PDB Structure

PDB 1AB4
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the breakage-reunion domain of DNA gyrase.
Cabral, J.H., Jackson, A.P., Smith, C.V., Shikotra, N., Maxwell, A., Liddington, R.C.
Nature