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CATH Superfamily 6.10.130.10

Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)

This superfamily represents the AZUL or amino-terminal zinc-binding domain of ubiquitin E3A ligase (Ube3A, also referred to as E6AP for E6 Associated Protein). is found in eukaryotes, and is an unusual zinc-finger domain. The final cysteine is usually mutated in Angelman syndrome patients. It is likely that AZUL plays a role in Ube3A substrate-recognition. The AZUL domain has a helix-loop-helix architecture with a Zn ion coordinated by four Cys residues arranged in Cys-X(4)-Cys-X(4)-Cys-X(28)-Cys motif PMID:21947926.

PFAM:PF16558,INTERPRO:IPR032353

GO Diversity

Unique GO annotations
37 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
876 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 1
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC: 1
Unique GO: 37
Taxonomy
Unique Species: 876