The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Arterivirus papain-like cysteine protease beta domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Arterivirus papain-like cysteine protease beta domain

Structural domains comprising this superfamily share the structure of the C-terminal papain-like cysteine protease (PCP) beta domain of the nsp1beta protein encoded by the Porcine reproductive and respiratory syndrome virus (PRRSV). PRRSV contains a single-stranded, positive-sense RNA genome that carries nine open reading frames (ORFs). Entry into host cells is followed by the release of the genome into the cytoplasm and the expression of the large replicase gene, consisting of ORFs 1a and 1b. Subsequent translation yields two multidomain replicase polyproteins, pp1a and pp1ab, with the latter being a C-terminally extended version of the former due to a ribosomal frameshift mechanism. These polyproteins are predicted to be cleaved into 14 nonstructural proteins (nsps) by the nsp4 3C-like main protease and three accessory proteinases residing in nsp1 (including nsp1alpha and nsp1beta) and nsp2. Nsp1 is a multifunctional protein which contains two papain-like cysteine proteases, designated PCPalpha and -beta, and a zinc finger motif required for subgenomic mRNA (sg mRNA) transcription. Sequence analyses revealed that nsp1alpha contains the N-terminal zinc finger and PCPalpha, while nsp1beta contains PCPbeta PMID:20410261.

GO Diversity

Unique GO annotations
1 Unique GO terms

EC Diversity

Unique EC annotations
4 Unique EC terms

Species Diversity

Unique species annotations
25 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 1
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC: 4
Unique GO: 1
Taxonomy
Unique Species: 25