View in Gene3D

CATH Superfamily 3.40.1350.50

D212 PD-(D/E)XK nuclease, catalytic motif

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
D212 PD-(D/E)XK nuclease, catalytic motif
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: D212 PD-(D/E)XK nuclease, catalytic motif

This superfamily includes proteins found in viruses and archaea, represented by Sulfolobus spindle-shaped virus ORF D212. According to literature, D212 is a type II restriction endonuclease that contains the PD-(D/E)XK catalytic motif and hence it belongs to this diverse PD-(D/E)XK nuclease superfamily. This fold and its associated catalytic residues are also found in nucleases, where they play roles in DNA replication, repair, recombination, and other processes requiring nuclease activity. The function of D212 in the phage replication cycle remains unknown, it is speculated to be a Holliday juction resolvase.

INTERPRO:IPR022012, PFAM:PF12187,DOI:10.1128/JVI.01663-09

GO Diversity

Unique GO annotations
0 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
19 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 2
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC:
Unique GO:
Taxonomy
Unique Species: 19