The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Two-component sensor protein CpxA, periplasmic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Two-component sensor protein CpxA, periplasmic domain

The Cpx system is one of extracytoplasmic stress response systems (ESR) found in Gram-negative bacteria. ESRs are operated by a two-component signaling system which consists of a sensory histidine kinase (HK) and a response regulator (RR) as basal elements. In the Cpx system, CpxA is the inner membrane-spanning, sensory HK. Members of this superfamily share the structure of the periplasmic domain of CpxA, involved in the recognition of a specific envelope stress. This event triggers signal transduction to the cytoplasmic domain, which results in the autophosphorylation of a conserved histidine residue (His248 in Escherichia coli CpxA). Then, the phosphate group is transferred to its cognate RR, CpxR, which controls the transcription of the genes involved in the ESRS PMID:22760860.

GO Diversity

Unique GO annotations
10 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
642 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 2
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 3
Function
Unique EC: 1
Unique GO: 10
Taxonomy
Unique Species: 642