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CATH Superfamily 3.30.450.140

PhoQ sensor domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: PhoQ sensor domain

Bacterial histidine kinases respond to environmental stimuli by transducing a signal from an extracytosolic sensor domain to a cytosolic catalytic domain. Among them, PhoQ promotes bacterial virulence and is tightly repressed by the divalent cations such as calcium and magnesium. PhoQ is an inner membrane protein with two transmembrane domains spanning the Gram-negative membrane.

This entry represents the PhoQ sensor domain which exhibits a mixed alpha/beta structure with a central five stranded beta-sheet core PMID:16406409.

GO Diversity

Unique GO annotations
10 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
412 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 15
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 1
Unique PDBs: 6
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC: 1
Unique GO: 10
Taxonomy
Unique Species: 412