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CATH Superfamily 3.30.200.110

Inositol-pentakisphosphate 2-kinase, N-lobe

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Inositol-pentakisphosphate 2-kinase, N-lobe
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Inositol-pentakisphosphate 2-kinase, N-lobe

This superfamily is represented by inositol-pentakisphosphate 2-kinases (also known as inositol 1,3,4,5,6-pentakisphosphate 2-kinase, Ins(1,3,4,5,6)P5 2-kinase) and InsP5 2-kinase). This enzyme phosphorylates Ins(1,3,4,5,6)P5 to form Ins(1,2,3,4,5,6)P6 (also known as InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, nonhomologous end-joining, endocytosis and ion channel regulation PMID:10960485. This entry describes the N-lobe, the N-terminal domain.

INTERPRO:IPR009286, PFAM:PF06090

GO Diversity

Unique GO annotations
25 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
701 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 23
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 14
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 17
Function
Unique EC: 1
Unique GO: 25
Taxonomy
Unique Species: 701