The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Tgt2/MlaC
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Tgt2/MlaC

This superfamily includes toluene tolerance protein Ttg2 and intermembrane phospholipid transport system binding protein MlaC.

MlaC is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane. These proteins are involved in toluene tolerance, which is mediated by increased cell membrane rigidity resulting from changes in fatty acid and phospholipid compositions, exclusion of toluene from the cell membrane, and removal of intracellular toluene by degradation PMID:9020089. Ttg2 is one of the many proteins involved in these processes PMID:9658016.

MlaC actively prevents phospholipid accumulation at the cell surface. It probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. It may transfer phospholipid across the periplasmic space and deliver it to the mlaFEDB complex at the inner membrane PMID:19383799.

INTERPRO:IPR008869, PFAM:PF05494

GO Diversity

Unique GO annotations
3 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
3607 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 4
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 2
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC:
Unique GO: 3
Taxonomy
Unique Species: 3607