The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Reeler domain
".
2.60.40.4060
superfamily
Functional Families
Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
Superfamily: Reeler domain
This superfamily represents the reeler (reelin) domain, a ~170 amino acid module which has been identified in the extracellular matrix proteins reelin and F-spondin (renamed Spon1) PMID:18602404,PMID:19020352. F-spondin is a secreted and extracellular matrix-attached protein that has been implicated in axonal pathfinding during neural development as well as in vascular remodelling in adult tissues PMID:19020352. The reelin domain is found in association with other modules, such as the thrombospondin type I repeat (TSP1), the spondin domain, the fibronectin type III domain or the Kunitz trypsin protease inhibitor domain. Its function is not yet known PMID:9441663,PMID:10409509. Although some of these proteins are specifically expressed in neural tissues, no specific biological function has been attributed to this domain PMID:19020352.
The reeler domain of F-spondin is composed of four-stranded and five-stranded antiparallel beta-sheets that are arranged in a beta-sandwich fold.
PFAM:PF02014, INTERPRO:IPR002861,DOI:10.1107/S0907444908028308
GO Diversity
Unique GO annotations
102 Unique GO terms
EC Diversity
Unique EC annotations
0 Unique EC terms
Species Diversity
Unique species annotations
591 Unique species
Sequence/Structure Diversity
Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.
Superfamily Summary
A general summary of information for this superfamily.
| Structures | |
|---|---|
| Domains: | 8 |
| Domain clusters (>95% seq id): | 1 |
| Domain clusters (>35% seq id): | 1 |
| Unique PDBs: | 3 |
| Alignments | |
| Structural Clusters (5A): | 1 |
| Structural Clusters (9A): | 1 |
| FunFam Clusters: | 17 |
| Function | |
| Unique EC: | |
| Unique GO: | 102 |
| Taxonomy | |
| Unique Species: | 591 |