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CATH Superfamily 1.20.225.30

Dihydrouridine synthase, C-terminal recognition domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Dihydrouridine synthase, C-terminal recognition domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Dihydrouridine synthase, C-terminal recognition domain

Dihydrouridine synthase (Dus) is responsible for introducing D (Dihydrouridine) modifications into RNA by the reduction of uridine.

The C-terminal tRNA-binding domain is formed by four parallel helices. This domain is commonly found in Dus-family proteins and is responsible for binding to the substrate tRNA. The role of dihydrouridine in tRNA is predicted to increase conformational flexibility of the tRNA.

INTERPRO:IPR001269,DOI:10.1107/S1744309113019489,DOI:10.1073/pnas.1500161112

GO Diversity

Unique GO annotations
4 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1362 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 8
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 5
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC:
Unique GO: 4
Taxonomy
Unique Species: 1362