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CATH Superfamily 1.20.120.1420

LntA helical domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
LntA helical domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: LntA helical domain

LntA is a virulence factor from the bacterium Listeria monocytogenes that stimulates interferon responses during infection by inhibiting BAHD1, a nuclear protein involved in gene silencing by promoting heterochromatin formation.

The secreted form of LntA can be subdivided into two domains; the trunk of the protein is formed by a bundle of helices, H1 to H3, while H4 and H5 protrude from one side of the protein. The positioning of the elbow relative to the trunk creates an elongated groove on LntA's surface, lined by charged patches. The K180/K181 dilysine motif on the surface of helix H5 is essential for BAHD1 recognition. According to pfam, the domain does not have a function at the moment, being categorised as DUF3219.

DOI:10.1128/mBio.00775-13

GO Diversity

Unique GO annotations
1 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
6 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 5
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 2
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC:
Unique GO: 1
Taxonomy
Unique Species: 6