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CATH Superfamily 1.20.120.1130

Vps28 C-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Vps28 C-terminal domain

The endosomal sorting complex I required for transport (ESCRT-I) is composed of the three subunits Vps23/Tsg101, Vps28 and Vps37. ESCRT-I is recruited to cellular membranes during multivesicular endosome biogenesis and by enveloped viruses such as HIV-1 to mediate budding from the cell. This entry represents the C-terminal domain (CTD) of Vps28 which is characterised by a high-sequence conservation throughout all kingdoms of life. Vps28-CTD forms a four helical bundle and serves as an adaptor module linked to the ESCRT-I complex that connects its function to other components of the Vps machinery, including ESCRT-III and Vps 20 PMID:16749904.

GO Diversity

Unique GO annotations
51 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1297 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 12
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 4
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 7
Function
Unique EC:
Unique GO: 51
Taxonomy
Unique Species: 1297