The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Antirestriction protein ArdA, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Antirestriction protein ArdA, domain 2

Structural domains comprising this superfamily share the structure of domain 2 of the antirestriction protein ArdA. This protein is found in prokaryotes, including important pathogenic species, and enables associated mobile genetic elements to evade the ubiquitous Type I DNA restriction systems thus assisting the spread of resistance genes in bacterial populations. ArdA forms a dimer and each monomer is comprised of three small domains arranged in a row in each monomer. Domains 2 and 3 have folds similar to those of nucleotide binding proteins, but which present a negative potential, opposite to the positive potential characteristic of nucleotide binding proteins. This reversal in surface potential suggests that ArdA is not a DNA- (or RNA)-binding protein PMID:19506028.

PFAM:PF07275,INTERPRO:IPR009899

GO Diversity

Unique GO annotations
1 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
450 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 4
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC:
Unique GO: 1
Taxonomy
Unique Species: 450